Can a multiple sclerosis diagnosis be reversed, leaving you no better?

Christina Applegate's doctors now tell her she does not have multiple sclerosis. The neurologist Marwa Kaisey, on the same podcast, says misdiagnosis is frequent, and puts the share at nearly 20%. No single test confirms the disease, so doctors work through a set of criteria.

Applegate says the news brought no relief. Nothing magical happened when she said, 'You don't have MS.' Nothing magical happened. She still needs a wheelchair to reach the doctor's office, and says she may be worse in some ways.

She says living with the diagnosis had stopped her life. I lost everything. I lost my job. Her doctors are still examining what went wrong, and what is causing her symptoms.