The PP leader and candidate for prime minister, Alberto Núñez Feijóo, has chosen the deputy Cayetana Álvarez de Toledo as his number two on the Madrid list for the general election on 29 November, the party confirmed. Borja Sémper, the PP's national spokesperson, stays in third place on the same list, as he did in 2023. Álvarez de Toledo, currently deputy spokesperson of the Popular Group in Congress, had been widely tipped for the slot and was sixth on the Madrid list in 2023. Feijóo had hinted at her on 20 October, citing her vote against the amnesty, and in an esRadio interview he described her as predictable and honest. In July 2023 he had picked Marta Rivera de la Cruz for the slot, but she later gave up her seat to focus on her work at Madrid city council.

On 21 October Vox's national executive committee approved its lead candidates for the 29 November election. In Andalusia, seven of the eight heads of list repeat from July 2023, the exception being Málaga, where Carlos Hernández Quero leads and Patricia Rueda is second. Blanca Armario González again heads the Cádiz list, Jacobo González-Robatto Perote the Granada list and Reyes Romero the Seville list. In Castile and León, Samuel Vázquez, the party's national spokesperson for security, immigration and home affairs, heads the Ávila list, while Miguel Suárez Arca leads Zamora. In Aragon, Carmen Rouco heads the Zaragoza list, Ester Blanco the Huesca list and Daniel Alda the Teruel list.