Researchers Identify Mechanism in Skin Nerves That Tells the Brain to Stop Scratching

Scientists have identified a specific molecular mechanism in skin nerve cells responsible for ending scratching in response to itching. This discovery sheds light on the long-known but poorly understood itch-scratch cycle, in which an irritating factor activates sensory neurons, triggering the need to scratch, which in turn brings relief. Research indicates the existence of a built-in inhibitory system that sends a signal to the brain that the itching has stopped and further scratching is no longer needed. This sensor is located in the skin's own nerve cells and is crucial for both sides of the process: both for generating the sensation of itching and for its suppression. As explained in publications, when we scratch, something "tells" the brain to stop. This discovery could have significant clinical implications. Key Scientific Event: February 21, 2026 — Presentation of research results at the Biophysical Society congress Scientists hope that a better understanding of this mechanism will pave the way for new therapies for millions of people suffering from chronic skin conditions accompanied by persistent itching, such as atopic dermatitis, eczema, or psoriasis. Current treatment methods often provide only partial relief. The sensation of itching and the scratch reflex are evolutionarily ancient and fundamental defense reactions of the body, aimed at removing parasites or irritating substances from the skin. However, chronic itch, unrelated to direct threat, constitutes a serious medical problem and can significantly reduce quality of life. The study, led by scientists including Roberta, was presented at the prestigious annual meeting of the Biophysical Society. This congress, being one of the world's leading conferences in the field of biophysics, serves as a platform for presenting the latest discoveries at the intersection of biology and physics. Further work will focus on detailed mapping of the neural and molecular pathways involved in this inhibitory process.